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If taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Along with their useful effects Esomeprazole can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Decreasing stomach acid can help ulcers to heal and reflux, or heartburn symptoms to subside. Your doctor will tell you how long it will take to feel the full benefit of Nexium. Our website, all orders are confidential.