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Prednisone may interact with estrogens and phenytoin. Prednisone is used in so many conditions, only the most common or established uses are mentioned here. Prednisolone works by acting within cells to prevent the release of substances in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Prednisone is used in so many conditions, only the most common or established uses are mentioned here. Corticosteroid. Prednisolone is a corticosteroid used to treat inflammation of the eye. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases.