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It is started within 48 hours of when the rash first appears. Valtrex is a very expensive drug if you do not have generic version called Valaciclovir. If Valtrex prevents the spread of the herpes virus. Once you have had chicken pox you will be immune to them for the rest of your life. Some of the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting. To always take a full course of the medication your doctor prescribes. To remember that Valtrex is not a cure since herpes has no known cure to date. If you are taking Valaciclovir for outbreak therapy, that usually means you take 1 g or alternatively 500 mg once a day, every day.